Raman analysis of human saliva samples

Saliva is a mixture of systemic molecules, sensitive in presence and concentration to the onset and progression of disease states, representing an easy collectable and highly informative biofluid. For these reasons, saliva is studied as a valuable source of diagnostic markers for multiple disorders.

Raman spectroscopy was proposed as a fast and sensitive technique for multiple disorders diagnosis and monitoing, as it can provide the whole biochemical characterization of saliva without focussing on a single molecule. The application of Raman spectroscopy on saliva, has been already proposed for different infective, neurological and cancer diseases, with promising results in the diagnostic and monitoring fields.


Labion is currently working on the Raman analysis of human saliva samples with different aims:

1. use of salivary Raman fingerprint of patient with Chronic Obstructive Pulmonary Disease (COPD) as qualitative and quantitative biomarker of the COPD conditions, variations and treatments from the pathology onset through the pharmacological and rehabilitative therapies

2. use of salivary Raman fingerprint for diagnosis and monitoring of Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s Disease

3. use of salivary Raman fingerprint for identification of SARS-CoV-2 infection