Live Free Webinar on SPRi by LABION 3 Oct 10AM and 5PM

Webinair

Live Free Webinar | Tuesday, October 3 | 10 AM & 5 PM CEST

“SPRi and examples of Alzheimer’s disease investigation and circulating antibodies bioassay optimization”

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Event Overview

This webinar will show the potentialities of the new multiplexing and fully automated SPRi “XelPleX” by illustrating two examples of the simultaneous characterization of multiple biologically relevant interactions.
 
The first example represents the discovery and the study of the interaction between the endogenous antimicrobial peptide cathelicidin (LL37) and different beta-amyloid aggregation forms spotted onto the SPRi chip surface. This study, performed in collaboration with Stanford University, University of Pavia and CNR, confirms that cathelicidin is a binding partner of beta-amyloid and suggests its potential role as inhibitor of beta-amyloid fibrils. (link to the published article)

 
The second example concerns the development and the optimization of a peptide microarray for the detection of circulating IgE antibodies in milk allergic patients. SPRi measurements permitted to select the best epitope presentation strategy (i.e. multiple epitope presentation) in order to obtain optimal analytical performances. This study was performed in collaboration with CNR and Ospedale San Raffaele. (link to the published article)

 

Key Learning Objectives

  • Learning how the SPRi platform provides flexibility to scientists to engineer a wide range of assays for the detection of various analytes at real time, simultaneously and with high throughput
  • Learn how to choose whether to perform kinetic or equilibrium SPR analyses
  • Learn how to perform kinetic analyses of high-affinity antibody/antigen interactions
Who Should Attend?

  • Academic and industrial researchers working with and developing bioassays for a wide range of analytes.
  • Scientists specializing or have expertise in the following fields: biomedical and clinical science, proteomics, genomics, biochemistry, …
Duration: 30 mins, followed by live Q&A
Presented by
Dr Renzo Vanna, Researcher at LABION,
IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
Moderated by
Dr Chiraz Frydman, SPRi Product Manager at HORIBA Scientific

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